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Center for Proteomics and Molecular Therapeutics Diseases

Alzheimer's

  • Marc Glucksman
    • Philibert KD, Marr RA, Norstrom EM, Glucksman MJ. Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches. [2014]. Medline
    • Mott NN, Pinceti E, Rao YS, Przybycien-Szymanska MM, Prins SA, Shults CL, Yang X, Glucksman MJ, Roberts JL, Pak TR. Age-dependent Effects of 17β-estradiol on the dynamics of estrogen receptor β (ERβ) protein-protein interactions in the ventral hippocampus. , 2014.

Cardiovascular & Stroke

  • Donghee Kim
    • Kang D, Wang J, Hogan JO, Kim D. TASK-1 (K2P3) and TASK-3 (K2P9) in Rabbit Carotid Body Glomus Cells. In: Arterial Chemoreceptors: New directions and Translational Perspectives. Edited by Gauda E., Monteiro M., Prabhakar N., Wyatt C., Schultz H. (eds) . Springer, Cham, Switzerland, 2018.
    • Wang J, Kim D. Activation of voltage-dependent K+ channels strongly limits hypoxia-induced elevation of [Ca2+ ]i in rat carotid body glomus cells. , 2018.
    • Kim D. Endocytosis: another pathway in receptor-Gq-TASK signalling. .
    • Wang J, Hogan JO, Wang R, White C, Kim D. Role of cystathionine-γ-lyase in hypoxia-induced changes in TASK activity, intracellular [Ca2+] and ventilation in mice. .
    • Gul R, Park DR, Shawl AI, Im SY, Nam TS, Lee SH, Ko JK, Jang KY, Kim D, Kim UH. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation. .
  • Darryl Peterson
    • Peterson, D.R. E.J. Sukowski, and D. Zikos. Blood-brain barrier transport pathways for cytoprotective thiols. Am J Ther. 2013 Sep-Oct;20(5):469-79. .
    • N. Ikpa, R. Forman, K. Garchow, E. Sukowski, and Peterson, D.R. In Vitro Studies on Degradation of Gamma-L-Glutamyl-L-Cysteine and Gamma-L-Glutamyl-D-Cysteine in Blood: Implications for Treatment of Stroke. . doi: 10.1097/MJT.0000000000000246.

Fibrosis

  • Darryl Peterson
    • B.L. Riser, F. Najmabadi, K. Garchow, J.L. Barnes, Peterson, D.R., and E. J. Sukowski. Treatment with the matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy. . doi: 10.1016/j.ajpath.2014.07.009. Epub 2014 Sep 2.

Infection

  • Min Lu
    • Radchenko, M., Nie, R. and Lu, M. (2016) Disulfide crosslinking of a multidrug and toxic compound extrusion transporter impacts multidrug efflux. .
    • Lu, M.(2015) Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications (review) .
    • Radchenko, M., Symersky, J., Nie, R. and Lu, M.. (2015) Structural basis for the blockade of MATE multidrug efflux pumps.
    • Symersky, J., Guo, Y., Wang, J. and Lu, M. (2015) Crystallographic study of a MATE transporter presents a difficult case in structure determination with low-resolution, anisotropic data and crystal twinning .

Kidney Disease

  • Henry Sackin
    • Sackin H. Hypothesis for renin-angiotensin inhibitor mitigation of COVID-19. Med Hypotheses. 2021 Jul;152:110609.
    • Nanazashvili, M., Sánchez-Rodríguez, J.E., Fosque, B., Bezanilla, F., Sackin, H. (2017). LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b. .
    • Sackin, H., Nanazashvili, M., and Makino, S. (2015). Direct injection of cell-free Kir1.1 protein into Xenopus oocytes replicates single-channel currents derived from Kir1.1 mRNA. .
    • Frindt, G., Li, H., Sackin, H., Palmer, L. G. (2013). Inhibition of ROMK channels by low extracellular K and oxidative stress. .

Metabolic Disease / Diabetes

  • Marc Glucksman
    • Shalata A, Ramirez MC, Desnick RJ, Priedigkeit N, Buettner C, Lindtner C, Mahroum M, Abdul-Ghani M, Dong F, Arar N, Camacho-Vanegas O, Zhang R, Camacho SC, Chen Y, Ibdah M, DeFronzo R, Gillespie V, Kelley K, Dynlacht BD, Kim S, Glucksman MJ, Borochowitz ZU, Martignetti JA. Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice. [2013].
  • Ronald Kaplan
    • Sun, J., Mayor, J.A., Kotaria, R., Walters, D.E., and Kaplan, R.S. Molecular Characterization of the Plasma Membrane Citrate Transporter. In preparation for submission to J. Biol. Chem. (2018).
    • Nie, R., Stark, S., Symersky, J., Kaplan, R.S., and Lu, M. Structure and function of the divalent anion/Na+ sympter from Vibrio cholera and a humanized variant. (2017).
  • Min Lu
    • Lu M. Structure and mechanism of the divalent anion/Na+ symporter. , 2019.

Rare/Orphan Diseases

  • Marc Glucksman
    • Rodriguez-Zabala M, Aza-Carmona M, Rivera-Pedroza CI, Belinchón A, Guerrero-Zapata I, Barraza-García J, Vallespin E, Lu M, Del Pozo A, Glucksman MJ, Santos-Simarro F, Heath KE. FGF9 mutation causes craniosynostosis along with multiple synostoses. . doi: 10.1002/humu.23292. Epub 2017 Jul 25.
    • Evans BR, Mosig RA, Lobl M, Martignetti CR, Camacho C, Grum-Tokars V, Glucksman MJ, Martignetti JA. Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. [2012].

Reproductive Health

  • Marc Glucksman
    • Woitowich NC, Philibert KD, Leitermann RJ, Wungjiranirun M, Urban JH, Glucksman MJ. EP24.15 as a Potential Regulator of Kisspeptin Within the Neuroendocrine Hypothalamus.