Factor XIII is a transglutaminase that plays a crucial role in the coagulation cascade by cross-linking fibrin and stabilizing the clot during the final stages of clot formation.

Altered levels of Factor XIII have been associated with various conditions: low levels in Crohn’s disease and ulcerative colitis, and elevated levels in Alzheimer’s disease.

The V34L polymorphism of the Factor XIII gene has been linked to myocardial infarction (conferring a protective effect) and may influence the disease progression in patients with venous leg ulcers.

• Clotted samples
• Specimens not collected in EDTA tubes
• Frozen specimens

Polymerase chain reaction (PCR) with reverse hybridization.

Reported as:

• Normal: GG
• Heterozygous Mutated: GT
• Homozygous Mutated: TT

• Juhan-Vague, I. Thromb Haemost 1999;81:463.
• Anwar, R et al. Blood 1999;93:897-905.

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