Fibrinogen (Factor I) is a glycoprotein synthesized in the liver that plays a central role in the coagulation cascade, converting to fibrin in the presence of thrombin. Elevated fibrinogen levels have been linked to an increased risk of atherosclerosis, deep vein thrombosis, and other cardiovascular diseases.

Fibrinogen consists of three pairs of polypeptide chains (α, β, γ), each encoded by separate genes located on chromosome 4. A G → A polymorphism at position -455 in the promoter region of the β-fibrinogen gene has been associated with elevated fibrinogen levels, particularly in AA homozygous carriers.

• Clotted samples
• Specimens not collected in EDTA tubes
• Frozen specimens

Polymerase chain reaction (PCR) with reverse hybridization.

Reported as:

• Normal: G/G
• Heterozygous Mutated: G/A
• Homozygous Mutated: A/A

• van’t Hooft F, et al. Arteriosler Thromb Vasc Biol 1999;19:3063-3070.

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